The region of Pcinja-Osogovo is situated in the Northeast of the country; this region is the most mountainous and the most arid. The vines are mainly grown on the mountain slopes with an altitude of 440 to 850m. The climate is continental temperate, colder than Central and Eastern regions with strong northern winds.

On average, there are 110 days with a temperature of over 25C in summer. Average precipitation levels are 550l/m each year, and between 300 and 400mm during the vegetation period. Periods of drought are rare during this time. The vines are mainly grown on diluvial, cinnamon and brown soil on limestone rocks. It is estimated that 6,1% of all wine production occurs here.

Traditional red grape varieties dominate, including Cabernet sauvignon, Gamay Noir, Gamay Teinturier, Pinot noir and Vranec. The white wine grapes grown here are Muscat Ottonel, Sauvignon Blanc, Riesling and Zilavka. This region encompasses the following disticts: Kumanovo, Kratovo and Pijanec.