The region of Pelagonija-Polog is situated in the South and Southwest of the country 6,4% of all wine produced comes from this region. The vines are grown at an altitude of between 600m and 680m, on the plateaus and small mountains that characterise this region. The climate is predominantly that of high mountains, characterised by cold and humid winters and hot and dry summers.

On average, 87 days have a temperature of over 25C. Annual precipitation levels are between 570 and 700mm. Brown soil is the predominant type, as well as vertisol, tchernozem and cinnamon in some cases. Red wine grapes grown in this region include Cabernet sauvignon, Gamay, Merlot, Pinot noir, Prokupec and Vranec.

The white wine grapes include Riesling, Chardonnay, Sauvignon Blanc, Zhilavka and Smederevka. The region of Pelagonija Polog includes six wine districts: Prilep, Bitola, Prespa, Ohrid, Kichevo and Tetovo.